Genetic clustering of European cancer patients indicates that opioid-mediated pain relief is independent of ancestry
نویسندگان
چکیده
منابع مشابه
Influence from genetic variability on opioid use for cancer pain: a European genetic association study of 2294 cancer pain patients.
Cancer pain patients need variable opioid doses. Preclinical and clinical studies suggest that opioid efficacy is related to genetic variability. However, the studies have small samples, findings are not replicated, and several candidate genes have not been studied. Therefore, a study of genetic variability with opioid doses in a large population using a confirmatory validation population was w...
متن کاملThioperamide-induced Antinociception is Mediated through Endogenous Opioid System in the Dentate Gyrus of Adult Rats
The present study investigated the effects of intra-dentate gyrus microinjection of naloxone (an opioid antagonist) and thioperamide (an antagonist of histamine H3 receptors) in the formalin test in rats. Subcutaneous injection of formalin (50 μl, 2.5 %) in the ventral surface of right hind paw produced a biphasic pattern (first phase: 0-5 min and second phase: 15 - 60 min) of licking/biting an...
متن کاملrandomized controlled trial study about compare of post operative pain after milligan morgan versus submucosal hemorrhoidectomy with & without pudendal nerve marcaine block in patients that had hemorrhoidectomy in imam hossein hospital of shahrood in 1389-90
مقدمه:هموروئید یکی از شایعترین بیماریهای جراحی ناحیه آنورکتال است که با درد و خونریزی بروز می کند. کاهش دردبعد عمل علاوه بر افزایش رضایت بیمار باعث کاهش مدت بستری و کاهش بار تحمیلی بر روی اقتصاد جامعه می گردد. مطالعه حاضر مقایسه ای از لحاظ میزان درد و میزان تأثیر مارکائین به عنوان روشی برای پروفیلاکسی درد بعداز عمل،دو روش هموروئیدکتومی باز و بسته انجام می دهد. مواد وروشها: این مطالعه کارآزمایی...
Pain Relief with Wet Cupping Therapy in Rats is Mediated by Heat Shock Protein 70 and ß-Endorphin
Background: Wet cupping therapy is a complementary therapy in pain management. The mechanism of this therapy, however, needs further elucidation. Cells injured by wet cupping therapy seem to stimulate the expression of heat shock protein 70 (HSP70). Its benefit in pain reduction could be mediated by the expression of ß-endorphin. This study aimed at determining the correlation between HSP70 and...
متن کاملEndogenous opioid activity in the anterior cingulate cortex is required for relief of pain.
Pain is aversive, and its relief elicits reward mediated by dopaminergic signaling in the nucleus accumbens (NAc), a part of the mesolimbic reward motivation pathway. How the reward pathway is engaged by pain-relieving treatments is not known. Endogenous opioid signaling in the anterior cingulate cortex (ACC), an area encoding pain aversiveness, contributes to pain modulation. We examined wheth...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The Pharmacogenomics Journal
سال: 2011
ISSN: 1470-269X,1473-1150
DOI: 10.1038/tpj.2011.27